Metabolism pharmacokinetics and toxicity of functional groups impact of chemical building blocks on admet chapter 10 alcohols and phenols absorption distribution metabolism and excretion. 1 metabolism pharmacokinetics and toxicity of functional groups impact of the building blocks of medicinal chemistry on admet how to obtain future titles on publication a standing order plan is available for this series a standing order will bring delivery of each new volume immediately on publication for further information please contact. Until now the area of drug metabolism and pharmacokinetics has been lacking in texts written for the medicinal chemist this outstanding book aimed at postgraduate medicinal chemists and those working in industry fills this gap in the literature written by medicinal chemists and admet scientists with a combined experience of around 300 years this aid to discovering drugs addresses the . Metabolism pharmacokinetics and toxicity of functional groups impact of chemical building blocks on admet chapter 4 primary secondary and tertiary amines and their isosteres amines are one of the most well represented functional groups amongst small drug molecules these compounds cover a wide range of therapeutic applications and . Metabolism pharmacokinetics and toxicity of functional groups impact of chemical building blocks on admet chapter 6 influence of aromatic rings on adme properties of drugs incorporation of a substituent or a functional group in an aromatic ring in place of hydrogen atom can significantly perturb the electronic steric hydrophobic